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DL-AP5 sodium salt


Product overview

  • Name
    DL-AP5 sodium salt
  • Short description
    Competitive NMDA receptor antagonist. Sodium salt.
  • Biological description

    DL-AP5 sodium salt is a water soluble, competitive NMDA receptor antagonist and is the sodium salt of DL-AP5. DL-AP5 sodium salt binds at the glutamate site and impairs learning and fear conditioning.

  • Alternative names
    DL-APV sodium salt
  • Biological action
  • Purity
  • Citations



  • Chemical name
    DL-2-Amino-5-phosphonopentanoic acid sodium salt
  • Molecular Weight
  • Chemical structure
    DL-AP5 sodium salt  [1303993-72-7]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • Appearance
    White solid


  • Application notes

    DL-AP5 sodium salt is a water soluble NMDA receptor antagonist. It is typically used at a concentration of 50–100 µM. DL-AP5 sodium salt from Hello Bio reduces evoked NMDAR current with full receptor antagonism at 50 µM (see Fig 1 above), consistent with the literature for this compound.


    #Protocol 1: Evoked NMDAR currents at +40 mV

    • NMDAR currents were recorded via whole cell voltage clamp recordings of CA1 pyramidal neurons from rat hippocampal brain slice.
    • NMDAR currents were evoked via a stimulating electrode placed in the CA3 region to stimulate the Schaffer collateral pathway.
    • Each NMDAR current was evoked via a single square (150 µs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDAR current.
    • Neurons were constantly held at +40 mV and NMDAR currents recorded in response to continual bath applications of NMDAR antagonists.
    • All NMDAR recordings were made in the presence of GABAA-R and AMPAR antagonists.

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Handling
    Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for DL-AP5 sodium salt

  • Infusion of the NMDA receptor antagonist, DL-APV, into the basolateral amygdala disrupts learning to fear a novel and a familiar context as well as relearning to fear an extinguished context.

    Laurent V et al (2009) Learn Mem 16(1) : 96-105.
    PubMedID: 19141468
  • The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear.

    Laurent V et al (2008) Learn Mem 15(5) : 304-14.
    PubMedID: 18463174
  • Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of NMDA ionotropic glutamate receptor.

    Blaise MC et al (2005) J Mol Model 11(6) : 489-502.
    PubMedID: 15928921
Our products in action
The following papers have cited the use of DL-AP5 sodium salt (HB0252) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

    Abrahamsson et al(2017) Neuron 09. : 030
    PubMedID: 29033205
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