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Biological Data Biological description Selective ALK2 inhibitor (IC50 = 108 nM). Blocks BMP signaling. Also promotes human induced pluripotent stem cell (iPSC ) neurogenesis when used in combination with SB 431542. Shows antitumor activity.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 4-[6-[4-(1-Methylethoxy)phenyl]pyra zolo[1,5-a ]pyrimidin-3-yl]-quinoline
Chemical structure
Molecular Formula C24 H20 N4 O
PubChem identifier 50997747
SMILES CC(C)OC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=NC5=C4C=CC=C5)C=N1
InChiKey JMIFGARJSWXZSH-UHFFFAOYSA-N
References for DMH-1 References are publications that support the biological activity of the product
DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer. Hao et al (2014) PLoS One 9(6) : e90748 DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Neely et al (2012) ACS Chem Neurosci 3(6) : 482-91 DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. Ao et al (2012) PLoS One 7(7) : e41627
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Selective ALK2 inhibitor. Promotes iPSC neurogenesis.