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Data

Product overview

  • Name
    DMH-1
  • Short description
    Selective ALK2 inhibitor. Promotes iPSC neurogenesis.
  • Biological description
    Selective ALK2 inhibitor (IC50 = 108 nM). Blocks BMP signaling. Also promotes human induced pluripotent stem cell (iPSC ) neurogenesis when used in combination with SB 431542. Shows antitumor activity.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    4-[6-[4-(1-Methylethoxy)phenyl]pyra zolo[1,5-a]pyrimidin-3-yl]-quinoline
  • Molecular Weight
    380.44
  • Chemical structure
    DMH-1 |  [1206711-16-1]
  • Molecular Formula
    C24H20N4O
  • CAS Number
    1206711-16-1

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for DMH-1

  • DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells.

    Ao et al (2012) PLoS One 7(7) : e41627
    PubMedID: 22848549
  • DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

    Neely et al (2012) ACS Chem Neurosci 3(6) : 482-91
    PubMedID: 22860217
  • DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer.

    Hao et al (2014) PLoS One 9(6) : e90748
    PubMedID: 24603907
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