Product overview

  • Name
    Dofetilide
  • Short description
    Selective potassium channel blocker
  • Biological description
    Selective potassium channel blocker. Inhibits Kv11.1 (hERG) channels (IC50 = 0.32 µM) and rapid delayed-rectifier K+ current (IKr). Increases the duration and refractory period of cardiac action potentials. Shows class III antiarrhythmic actions.
  • Biological action
    Blocker
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino] ethane
  • Molecular Weight
    441.56
  • Chemical structure
    Dofetilide  [115256-11-6]
  • Molecular Formula
    C19H27N3O5S2
  • CAS Number
    115256-11-6
  • PubChem identifier
    71329
  • SMILES
    CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
  • InChi
    InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
  • InChiKey
    IXTMWRCNAAVVAI-UHFFFAOYSA-N
  • MDL number
    MFCD00869707

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM)

References for Dofetilide

  • UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.

    Gwilt M et al (1991) J Pharmacol Exp Ther 256(1) : 318-24.
    PubMedID: 1988662
  • Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels.

    Ficker E et al (2001) Mol Pharmacol 60(6) : 1343-8.
    PubMedID: 11723241
  • Effects of the antiarrhythmic drug dofetilide on transmural dispersion of repolarization in ventriculum. A computer modeling study.

    Saiz J et al (2011) IEEE Trans Biomed Eng 58(1) : 43-53.
    PubMedID: 20851784
  • Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide.

    Carmeliet E (1992) J Pharmacol Exp Ther 262(2) : 809-17.
    PubMedID: 1501123

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