Product overview

Name Donepezil hydrochloride
Purity >98%
Description

Potent AChE inhibitor

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Biological Data

Biological description

Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM) which increases acetylcholine levels. Displays >1200-fold selectivity for AChE over butyrylcholinesterase (BuChE). Orally active. Shows anti-inflammatory properties, neuroprotective activity and attenuates amyloid-β load in vitro and in vivo. In combination, donepezil and LSL60101 decrease amyloid-β40 and amyloid-β42 levels, amyloid-β plaque number and tau hyperphosphorylation to attenuate amyloid-β pathology in 5XFAD brains. Chronic low-dose treatment with LSL60101 and donepezil reversed cognitive deficits and impaired social behaviour.

Solubility & Handling

Storage instructions Room Temperature
Solubility overview Soluble in water (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Chemical Data

Purity >98%
Chemical name 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
Molecular Weight 415.95
Chemical structure Donepezil hydrochloride [120011-70-3] Chemical Structure
Molecular Formula C24H29NO3.HCl
CAS Number 120011-70-3
PubChem identifier 5741
SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
InChi InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
InChiKey XWAIAVWHZJNZQQ-UHFFFAOYSA-N
MDL number MFCD17215939
Appearance White solid

References for Donepezil hydrochloride

References are publications that support the biological activity of the product
  • Disease-modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil.

    Vasilopoulou F et al (2021) British journal of pharmacology 178 : 3017-3033
  • Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.

    Sugimoto H et al (2000) Current medicinal chemistry 7 : 303-39
  • Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.

    Sugimoto H et al (1995) Journal of medicinal chemistry 38 : 4821-9

3 Item(s)