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Dorsomorphin dihydrochloride

(HB2800)
Data

Product overview

  • Name
    Dorsomorphin dihydrochloride
  • Short description
    Potent, selective AMPK inhibitor. Also promotes cardiomyocyte differentiation in mouse embroynic stem cells (mESCs).
  • Biological description
    Potent, selective and reversible AMPK inhibitor (Ki = 109 nM). Inhibits AICAR and metformin induced AMPK activation. Additionally shows activity at ALK2, ALK3 and ALK6. Also promotes cardiomyocyte differentiation in mouse embroynic stem cells (mESCs).
  • Alternative names
    Compound C | BML-275
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    6-[4-[2-(1-Piperidinyl)ethoxy]pheny l]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
  • Molecular Weight
    472.41
  • Chemical structure
    Dorsomorphin dihydrochloride | Compound C, BML-275  [1219168-18-9]
  • Molecular Formula
    C24H25N5O.2HCl
  • CAS Number
    1219168-18-9
  • PubChem identifier
    49761481
  • SMILES
    C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
  • InChiKey
    RJDVIJJQKMGPMV-UHFFFAOYSA-N
  • MDL number
    MFCD11112197
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM), and in DMSO (20mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Dorsomorphin dihydrochloride

  • Role of AMP-activated protein kinase in mechanism of metformin action.

    Zhou et al (2001) J Clin Invest 108(8) : 1167-74
    PubMedID: 11602624
  • Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.

    Vucicevic et al (2011) Autophagy 7(1) : 40-50
    PubMedID: 20980833
  • Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.

    Hao et al (18682835) PLoS One 3(8) : e2904
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