In my cart

You have no items in your shopping cart.

Doxorubicin hydrochloride

(HB4183)
Data

Product overview

  • Name
    Doxorubicin hydrochloride
  • Short description
    Antibiotic. DNA topisomerase II inhibitor.
  • Biological description

    Antibiotic and DNA topisomerase II inhibitor.

    Intercalates into DNA to inhibit nucleic acid synthesis.

    Induces apoptosis and shows antitumor and anti-neoplastic activity

  • Alternative names
    Adriamycin, NSC 123127, DOX, DXR
  • Biological action
    Antibiotic
  • Applications
    Antineoplastic Agent
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    10-[(3-Amino-2,3,6-trideoxy-?-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
  • Molecular Weight
    579.99
  • Molecular Formula
    C27H29NO11.HCl
  • CAS Number
    25316-40-9
  • PubChem identifier
    443939
  • SMILES
    C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
  • InChiKey
    MWWSFMDVAYGXBV-RUELKSSGSA-N
  • MDL number
    MFCD00077757
  • Appearance
    Orange

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (50 mM) and water (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Doxorubicin hydrochloride

  • Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity.

    Patel et al (1997) Mol Pharmacol 52(4) : 658-66
    PubMedID: 9380029
  • Studies on the in vitro reactivity of clofibryl and fenofibryl glucuronides. Evidence for protein binding via a Schiff's base mechanism.

    Grubb et al (1993) Biochem Pharmacol 46(3) : 357-64
    PubMedID: 8347161
Support & Resources

Reviews & Product Guides