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Data

Product overview

  • Name
    DPCPX
  • Short description
    Potent, selective A1 receptor antagonist
  • Biological description
    Potent and selective A1 adenosine receptor antagonist (Ki values are 0.45 and 300 nM at A1 and A2 receptors respectively). Active in vivo. Facilitates long term potentiation (LTP) and blocks induction of long term depression (LTD).
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    8-Cyclopentyl-1,3-dipropylxanthine
  • Molecular Weight
    304.39
  • Chemical structure
    DPCPX [102146-07-6]
  • Molecular Formula
    C16H24N4O2
  • CAS Number
    102146-07-6
  • PubChem identifier
    1329
  • SMILES
    CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3
  • Source
    Synthetic
  • InChi
    InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
  • InChiKey
    FFBDFADSZUINTG-UHFFFAOYSA-N
  • MDL number
    MFCD00055117
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (5 mM) and in ethanol (10 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for DPCPX

  • Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.

    von der Leyen et al (1989) Naunyn Schmiedebergs Arch Pharmacol. 340(2) : 204-9
    PubMedID: 2554151
  • 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors.

    Lohse et al (1987) Naunyn Schmiedebergs Arch Pharmacol. 336(2) : 204-10
    PubMedID: 2825043
  • Caffeine, adenosine receptors, and synaptic plasticity.

    Costenla et al (2010) J Alzheimers Dis 1 : S25-34
    PubMedID: 20182030
  • Activation of receptors negatively coupled to adenylate cyclase is required for induction of long-term synaptic depression at Schaffer collateral-CA1 synapses.

    Santschi et al (2006) J Neurobiol 66(3) : 205-19
    PubMedID: 16329119
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