Product overview

  • Name
    DPN
  • Short description
    Selective ERβ estrogen receptor agonist
  • Biological description
    Selective ERβ estrogen receptor agonist (Kd values are 5 and 400 nM at ERβ and ERα respectively). Shows 70-fold selectivity at ERβ over ERα. Shows neuroprotective effects. Active in vivo.
  • Biological action
    Agonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    2,3-bis(4-Hydroxyphenyl)-propionitrile
  • Molecular Weight
    239.27
  • Chemical structure
    DPN [1428-67-7]
  • Molecular Formula
    C15H13NO2
  • CAS Number
    1428-67-7
  • PubChem identifier
    102614
  • SMILES
    C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O
  • InChi
    InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
  • InChiKey
    GHZHWDWADLAOIQ-UHFFFAOYSA-N
  • MDL number
    MFCD01695412

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100 mM) and in ethanol (100 mM)

References for DPN

  • Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.

    Meyers MJ et al (2001) J Med Chem 44(24) : 4230-51.
    PubMedID: 11708925
  • Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons.

    Zhao L et al (2004) Brain Res 1010(1-2) : 22-34.
    PubMedID: 15126114
  • The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease.

    Baraka AM et al (2011) Life Sci 88(19-20) : 879-85.
    PubMedID: 21420980
  • Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.

    Sepehr E et al (2012) J Pharm Biomed Anal 71 : 119-26.
    PubMedID: 22981216

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