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Product overview

  • Name
  • Short description
    Cell permeable, potent and selective dynamin GTPase inhibitor
  • Biological description
    Cell permeable, potent and selective dynamin GTPase inhibitor. Acts in non-competitive reversible manner. Displays activity for both dynamin 1, dynamin 2 (approx IC50 value = 15 µM respectively) and mitochondrial dynamin (DRP1). Exhibits little or no activity at other small GTPases. Blocks endocytosis. Inhibits transferrin uptake (IC50 = 15 µM) and potently destabilises F-actin. Displays cardioprotective properties
  • Biological action
  • Purity
  • Citations


  • Chemical name
    3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
  • Molecular Weight
  • Chemical structure
    Dynasore  [304448-55-3]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Dynasore

  • Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments.

    Yamada H et al (2009) Biochem Biophys Res Commun 390(4) : 1142-8.
    PubMedID: 19857461
  • Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart.

    Gao D et al (2013) PLoS One 8(4) : e60967.
    PubMedID: 23596510
  • Dynasore inhibits removal of wild-type and DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane.

    Young A et al (2009) Biochem J 421(3) : 377-85.
    PubMedID: 19442237
  • Dynasore, a cell-permeable inhibitor of dynamin.

    Macia E et al (2006) Dev Cell 10(6) : 839-50.
    PubMedID: 16740485
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