Product overview

Name Dynasore
Purity >99%
Description Cell-permeable, non-competitive dynamin inhibitor
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Dynasore product vial image | Hello Bio

Biological Data

Biological description

Overview

Cell-permeable, non-competitive dynamin inhibitor which inhibits the GTPase activity of dynamin 1, dynamin 2 and Drp1 (mitochondrial dynamin). It does not inhibit other small GTPases.

Uses and applications

Fast acting and reversible by washout.

Dynasore inhibits clathrin- and dynamin-dependent endocytosis in cells including neurons.

Dynasore has additionally been shown to inhibit proliferation, induce apoptosis of lung cancer cells and to enhance the inhibitory effects of cisplatin.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Molecular Weight 322.32
Chemical structure Dynasore  [304448-55-3] Chemical Structure
Molecular Formula C18H14N2O4
CAS Number 304448-55-3
PubChem identifier 135533054
SMILES C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
InChi InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChiKey SYNDQCRDGGCQRZ-VXLYETTFSA-N
MDL number MFCD11045288
Appearance Off-white solid

References for Dynasore

References are publications that support the biological activity of the product
  • Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart.

    Gao D et al (2013) PLoS One 8(4) : e60967.
  • Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments.

    Yamada H et al (2009) Biochem Biophys Res Commun 390(4) : 1142-8.
  • Dynasore inhibits removal of wild-type and DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane.

    Young A et al (2009) Biochem J 421(3) : 377-85.
  • Dynasore, a cell-permeable inhibitor of dynamin.

    Macia E et al (2006) Dev Cell 10(6) : 839-50.

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