Cell-permeable, non-competitive dynamin inhibitor which inhibits the GTPase activity of dynamin 1, dynamin 2 and Drp1 (mitochondrial dynamin). It does not inhibit other small GTPases.
Uses and applications
Fast acting and reversible by washout.
Dynasore inhibits clathrin- and dynamin-dependent endocytosis in cells including neurons.
Dynasore has additionally been shown to inhibit proliferation, induce apoptosis of lung cancer cells and to enhance the inhibitory effects of cisplatin.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.