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(E)-Capsaicin

(HB1179)
Data

Product overview

  • Name
    (E)-Capsaicin
  • Short description
    TRPV1 channel agonist
  • Biological description
    TRPV1 channel agonist (pEC50 values are 7.10 and 7.97 for human and rat TRPV1 respectively). Carbonic anhydrase inhibitor (Ki values are 696.15 and 208.37 µM for hCAI an hCAII respectively). Also CYP3A subfamily and P-gp inhibitor. Induces cell cycle arrest, apoptosis and inhibits proliferation Displays apoptosis inducing,
  • Biological action
    Agonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
  • Molecular Weight
    305.42
  • Chemical structure
    (E)-Capsaicin  [404-86-4]
  • Molecular Formula
    C18H27NO3
  • CAS Number
    404-86-4
  • PubChem identifier
    1548943
  • SMILES
    CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
  • InChi
    InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
  • InChiKey
    YKPUWZUDDOIDPM-SOFGYWHQSA-N
  • MDL number
    MFCD00017259

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (50mM) and in ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for (E)-Capsaicin

  • Capsaicin: a potent inhibitor of carbonic anhydrase isoenzymes.

    Arabaci B et al (2014) Molecules 19(7) : 10103-14.
    PubMedID: 25014536
  • Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.

    Bode AM et al (2009) Cancer Res 69(3) : 905-13.
    PubMedID: 19155296
  • Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

    Holzer P (1991) Pharmacol Rev 43(2) : 143-201.
    PubMedID: 1852779
  • Sensory neuron-specific actions of capsaicin: mechanisms and applications.

    Bevan S et al (1990) Trends Pharmacol Sci 11(8) : 330-3.
    PubMedID: 2203194
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