E-4031 dihydrochloride

(HB1080)

Product overview

  • Name
    E-4031 dihydrochloride
  • Short description
    Potent, selective Kv11.1 channel blocker
  • Biological description
    Potent and selective Kv11.1 (hERG) channel blocker (IC50 = 7.7 nM in HEK 293 cells). Delayed rectifier K2+ current inhibitor. Shows antiarrhythmic actions.
  • Biological action
    Blocker
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
  • Molecular Weight
    474.44
  • Chemical structure
    E-4031 dihydrochloride  [113559-13-0]
  • Molecular Formula
    C21H27N3O3S.2HCl
  • CAS Number
    113559-13-0

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in water (100mM) or DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for E-4031 dihydrochloride

  • Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.

    Kim I et al (2005) J Appl Physiol (1985) 98(4) : 1469-77.
    PubMedID: 15591286
  • Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.

    Wettwer E et al (1991) J Cardiovasc Pharmacol 17(3) : 480-7.
    PubMedID: 1711611
  • Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.

    Zhou Z et al (1998) Biophys J 74(1) : 230-41.
    PubMedID: 9449325

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