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E-4031 dihydrochloride

(HB1080)
Data

Product overview

  • Name
    E-4031 dihydrochloride
  • Short description
    Potent, selective Kv11.1 channel blocker
  • Biological description
    Potent and selective Kv11.1 (hERG) channel blocker (IC50 = 7.7 nM in HEK 293 cells). Delayed rectifier K2+ current inhibitor. Shows antiarrhythmic actions.
  • Biological action
    Blocker
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
  • Molecular Weight
    474.44
  • Chemical structure
    E-4031 dihydrochloride  [113559-13-0]
  • Molecular Formula
    C21H27N3O3S.2HCl
  • CAS Number
    113559-13-0
  • PubChem identifier
    3087190
  • SMILES
    CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.Cl.Cl
  • Source
    Synthetic
  • InChi
    InChI=1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
  • InChiKey
    ZQBNWMFBOSOOLX-UHFFFAOYSA-N
  • MDL number
    MFCD01754739
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (100mM), and in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for E-4031 dihydrochloride

  • Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.

    Kim I et al (2005) J Appl Physiol (1985) 98(4) : 1469-77.
    PubMedID: 15591286
  • Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.

    Wettwer E et al (1991) J Cardiovasc Pharmacol 17(3) : 480-7.
    PubMedID: 1711611
  • Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.

    Zhou Z et al (1998) Biophys J 74(1) : 230-41.
    PubMedID: 9449325
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