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E-4031 dihydrochloride

(HB1080)
Technical documents: SDS CoA Datasheet

Product overview

Name E-4031 dihydrochloride
Purity >98%
Description Potent, selective Kv11.1 channel blocker
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E-4031 dihydrochloride product vial image | Hello Bio

Biological Data

Biological description Potent and selective Kv11.1 (hERG) channel blocker (IC50 = 7.7 nM in HEK 293 cells). Delayed rectifier K2+ current inhibitor. Shows antiarrhythmic actions.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM), and in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
Molecular Weight 474.44
Chemical structure E-4031 dihydrochloride  [113559-13-0] Chemical Structure
Molecular Formula C21H27N3O3S.2HCl
CAS Number 113559-13-0
PubChem identifier 3087190
SMILES CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.Cl.Cl
Source Synthetic
InChi InChI=1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
InChiKey ZQBNWMFBOSOOLX-UHFFFAOYSA-N
MDL number MFCD01754739
Appearance White solid

References for E-4031 dihydrochloride

References are publications that support the biological activity of the product
  • Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.

    Kim I et al (2005) J Appl Physiol (1985) 98(4) : 1469-77.
  • Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.

    Zhou Z et al (1998) Biophys J 74(1) : 230-41.
  • Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.

    Wettwer E et al (1991) J Cardiovasc Pharmacol 17(3) : 480-7.

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