E6 Berbamine

(HB0269)

Product overview

  • Name
    E6 Berbamine
  • Short description
    Potent, selective CaM antagonist
  • Biological description
    Potent and selective calmodulin (CaM) antagonist. Inhibits MLCK activity (Ki = 0.95 µM) and P-glycoprotein (P-gp) activity in vascular endothelial cells. Inhibits α3-containing neuronal nicotinic acetylcholine receptors (α3-nAChRs). Cell-permeable.
  • Alternative names
    E6; Berbamine compound E6
  • Biological action
    Antagonist
  • Our products in action

Properties

  • Chemical name
    6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-yl acetate; Calmodulin inhibitor
  • Molecular Weight
    757.83
  • Chemical structure
    E6 Berbamine  [73885-53-7]
  • Molecular Formula
    C44H43N3O9
  • CAS Number
    73885-53-7

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO (25mg/ml) or ethanol (25mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for E6 Berbamine

  • Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase.

    Hu ZY et al (1992) Biochem Pharmacol 44(8) : 1543-7.
    PubMedID: 1417979
  • Effect of E6, a novel calmodulin inhibitor, on activity of P-glycoprotein in purified primary cultured rat brain microvessel endothelial cells.

    Zhu HJ et al (2003) Acta Pharmacol Sin 24(11) : 1143-9.
    PubMedID: 14627500
  • Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives.

    Virginio C et al (2005) Neurosci Lett 381(3) : 299-304.
    PubMedID: 15896488

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