Ebselen

(HB0270)

Product overview

  • Name
    Ebselen
  • Short description
    Broad enzyme inhibitor
  • Biological description
    Antioxidant and anti-inflammatory agent. Inhibits PKC, NADPH, NADPH oxidase, NO synthases, 5-lipoxygenase and cyclooxygenase. Mimics glutathione peroxidase. Shows neuroprotective and anti-cancer actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    2-Phenyl-1,2-benzisoselenazol-3(2H)-one
  • Molecular Weight
    274.2
  • Chemical structure
    Ebselen  [60940-34-3]
  • Molecular Formula
    C13H9NOSe
  • CAS Number
    60940-34-3
  • PubChem identifier
    3194
  • SMILES
    C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
  • InChi
    InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
  • InChiKey
    DYEFUKCXAQOFHX-UHFFFAOYSA-N
  • MDL number
    MFCD00210937

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ebselen

  • Molecular actions of ebselen--an antiinflammatory antioxidant.

    Schewe T (1995) Gen Pharmacol 26(6) : 1153-69.
    PubMedID: 7590103
  • Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?

    Cotgreave IA et al (1989) Biochem Pharmacol 38(4) : 649-56.
    PubMedID: 2537084
  • Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils.

    Park S et al (2014) Free Radic Res 48(8) : 864-74.
    PubMedID: 24807533
  • Induction of apoptosis in human multiple myeloma cell lines by ebselen via enhancing the endogenous reactive oxygen species production.

    Zhang L et al (2014) Biomed Res Int 2014 : 696107
    PubMedID: 24587987

Reviews & Product Guides