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EHNA hydrochloride

(HB3540)
Data

Product overview

  • Name
    EHNA hydrochloride
  • Short description
    Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation.
  • Biological description
    Potent adenosine deaminase (ADA) and PDE2 inhibitor (Ki = 1.6 nM at ADA and IC50 values are 0.8 and 4 ΜM at human and porcine PDE2 respectively. Reversibly supresses spontaneous hESCs differentiation. Also acts as a strong blocker of directed neuronal differentiation.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    erythro-9-(2-Hydroxy-3-nonyl)adenin e hydrochloride
  • Molecular Weight
    313.83
  • Chemical structure
    EHNA hydrochloride |  [58337-38-5]
  • Molecular Formula
    C14H23N5O.HCl
  • CAS Number
    58337-38-5

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in water (100mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for EHNA hydrochloride

  • Probing the active site of adenosine deaminase by a pH responsive fluorescent competitive inhibitor.

    Caiolfa et al (1998) Biophys Chem 70(1) : 41-56
    PubMedID: 9474762
  • Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.

    Burton et al (2010) Biochem J 432(3) : 575-84
    PubMedID: 20923411
  • Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats.

    Woodson et al (1998) Behav Neurosci 112(2) : 339-409
    PubMedID: 9588486
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