Eliprodil

(HB0274)

Product overview

  • Name
    Eliprodil
  • Short description
    Non-competitive, GluN2B subunit selective NMDA receptor antagonist
  • Biological description
    Non-competitive and GluN2B subunit selective NMDA receptor antagonist. Binds at the polyamine site. IC50 values are 1, >100 and >100 µM for GluN2B, GluN2A and GluN2C respectively. Also Inhibits voltage- dependent Ca2+ channels. Shows neuroprotective actions and potentiates anticonvulsant effects of CGP 37849.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
  • Molecular Weight
    347.86
  • Chemical structure
    Eliprodil  [119431-25-3]
  • Molecular Formula
    C20H23ClFNO
  • CAS Number
    119431-25-3
  • PubChem identifier
    60703
  • SMILES
    C1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O
  • InChi
    InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2
  • InChiKey
    GGUSQTSTQSHJAH-UHFFFAOYSA-N
  • MDL number
    MFCD00866651

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Eliprodil

  • Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window.

    Toulmond S et al (1993) Prevention by eliprodil (SL 82 620(1) : 32-41.
    PubMedID: 8402196
  • Antagonism of NMDA receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.

    Whittemore ER et al (1997) J Pharmacol Exp Ther 282(1) : 326-38.
    PubMedID: 9223571
  • Central effects of SL 82.0715, an antagonist of polyamine site of the NMDA receptor complex.

    Dereń-Wesołek A et al (1993) Central effects of SL 82 45(5-6) : 467-80.
    PubMedID: 7912135
  • The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia.

    Bath CP et al (1996) Eur J Pharmacol 299(1-3) : 103-12.
    PubMedID: 8901012