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Endomorphin-1

(HB2410)
Data

Product overview

  • Name
    Endomorphin-1
  • Short description
    Potent, selective μ-opioid receptor agonist
  • Biological description
    Potent, selective μ-opioid receptor agonist (Ki values are 360 pM and >1000 nM at μ, δ and κ receptors respectively). Endogenous peptide. Shows >4000 and 15,000-fold selectivity for μ over δ and κ receptors. Shows antinociceptive activity.
  • Biological action
    Agonist
  • Citations

Properties

  • Chemical name
    Tyr-Pro-Trp-Phe-NH2
  • Molecular Weight
    610.67
  • Molecular Formula
    C34H38N6O5
  • CAS Number
    189388-22-5
  • PubChem identifier
    5311080
  • SMILES
    C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)N
  • InChiKey
    ZEXLJFNSKAHNFH-SYKYGTKKSA-N

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in water
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Endomorphin-1

  • A potent and selective endogenous agonist for the mu-opiate receptor.

    Zadina et al (1997) Nature 386 : 499-502
    PubMedID: 9087409
  • Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.

    Wang et al (2014) PLoS 9 : e103773
    PubMedID: 25090615
  • Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists.

    Horvath (2000) Pharmacol Ther 88 : 437-63
    PubMedID: 11337033
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