Endomorphin-1

(HB2410)

Order: HB2410

Pack	Price	Qty
5mg	$66

(HB2410)

Data

Product overview

Name
Endomorphin-1
Short description
Potent, selective μ-opioid receptor agonist
Biological description
Potent, selective μ-opioid receptor agonist (K_i values are 360 pM and >1000 nM at μ, δ and κ receptors respectively). Endogenous peptide. Shows >4000 and 15,000-fold selectivity for μ over δ and κ receptors. Shows antinociceptive activity.
Biological action
Agonist
Citations
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Chemical name
Tyr-Pro-Trp-Phe-NH₂
Molecular Weight
610.67
Molecular Formula
C₃₄H₃₈N₆O₅
CAS Number
189388-22-5
PubChem identifier
5311080
SMILES
C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)N
InChiKey
ZEXLJFNSKAHNFH-SYKYGTKKSA-N

Storage instructions
-20°C (desiccate)
Solubility overview
soluble in water
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

A potent and selective endogenous agonist for the mu-opiate receptor.

Zadina et al (1997) Nature 386 : 499-502
PubMedID: 9087409
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.

Wang et al (2014) PLoS 9 : e103773
PubMedID: 25090615
Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists.

Horvath (2000) Pharmacol Ther 88 : 437-63
PubMedID: 11337033

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