Endomorphin-1
(HB2410)
Endomorphin-1
(HB2410)- Data
- Support & Resources
Data
Product overview
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Name
Endomorphin-1
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Short description
Potent, selective μ-opioid receptor agonist
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Biological description
Potent, selective μ-opioid receptor agonist (Ki values are 360 pM and >1000 nM at μ, δ and κ receptors respectively). Endogenous peptide. Shows >4000 and 15,000-fold selectivity for μ over δ and κ receptors. Shows antinociceptive activity.
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Biological action
Agonist
- Citations
Properties
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Chemical name
Tyr-Pro-Trp-Phe-NH2
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Molecular Weight
610.67
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Molecular Formula
C34H38N6O5
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CAS Number
189388-22-5
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PubChem identifier
5311080
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SMILES
C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CC=CC=C5)C(=O)N
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InChiKey
ZEXLJFNSKAHNFH-SYKYGTKKSA-N
Storing and Using Your Product
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Storage instructions
-20°C (desiccate)
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Solubility overview
soluble in water
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Endomorphin-1
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A potent and selective endogenous agonist for the mu-opiate receptor.
Zadina et al (1997) Nature 386 : 499-502PubMedID: 9087409 -
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
Wang et al (2014) PLoS 9 : e103773PubMedID: 25090615 -
Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists.
Horvath (2000) Pharmacol Ther 88 : 437-63PubMedID: 11337033
Support & Resources
Reviews & Product Guides
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