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Biological Data Biological description Selective mineralcorticoid receptor antagonist (IC50 = 990 nM). Shows little to no effect at androgen, estrogen or progesterone receptors. Shows cardioprotective and anti-apoptotic effects.
Solubility & Handling Storage instructions Room temperature
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-o xo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Chemical structure
Molecular Formula C24 H30 O6
PubChem identifier 443872
SMILES O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1
InChiKey JUKPWJGBANNWMW-VWBFHTRKSA-N
References for Eplerenone References are publications that support the biological activity of the product
Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes. Ramã?rez E et al (2013) Cardiovasc Diabetol 12 : 172 A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. Fagart J et al (2010) J Biol Chem 285(39) : 29932-40. Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. McMahon EG (2001) Curr Opin Pharmacol 1(2) : 190-6.
Selective mineralcorticoid receptor antagonist
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