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Eplerenone

(HB2527)
Data

Product overview

  • Name
    Eplerenone
  • Short description
    Selective mineralcorticoid receptor antagonist
  • Biological description
    Selective mineralcorticoid receptor antagonist (IC50 = 990 nM). Shows little to no effect at androgen, estrogen or progesterone receptors. Shows cardioprotective and anti-apoptotic effects.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-o xo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
  • Molecular Weight
    414.5
  • Chemical structure
    Eplerenone
  • Molecular Formula
    C24H30O6
  • CAS Number
    107724-20-9

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Eplerenone

  • Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.

    McMahon EG (2001) Curr Opin Pharmacol 1(2) : 190-6.
    PubMedID: 11714095
  • A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule.

    Fagart J et al (2010) J Biol Chem 285(39) : 29932-40.
    PubMedID: 20650892
  • Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes.

    Ramã?rez E et al (2013) Cardiovasc Diabetol 12 : 172
    PubMedID: 24261558
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