Epoxomicin

(HB3890)

Product overview

  • Name
    Epoxomicin
  • Short description
    Potent, selective and irreversible 20S proteasome inhibitor
  • Biological description
    Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy.
  • Purity
    >97%
  • Our products in action

Properties

  • Molecular Weight
    554.7
  • Chemical structure
    Epoxomicin [134381-21-8]
  • CAS Number
    134381-21-8
  • InChiKey
    DOGIDQKFVLKMLQ-JTHVHQAWSA-N
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

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