In my cart

You have no items in your shopping cart.



Product overview

  • Name
  • Short description
    Selective PLC inhibitor
  • Biological description
    Selective phosphatidylinositol phospholipase (PLC) inhibitor (IC50 = 9.6 µM). Inhibits mitochondrial respiration, ERK1/2 and p38 MAPK. Also activates Fas/CD95 death receptor. Displays antitumor and apoptosis -inducing properties.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    Edelfosine; 1-octadecyl-2-O-methyl-glycero-3-phosphocholine
  • Molecular Weight
  • Chemical structure
    ET-18-OCH3  [77286-66-9]
  • Molecular Formula
  • CAS Number
  • PubChem identifier

Storing and Using Your Product

  • Solubility overview
    soluble in ethanol or DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ET-18-OCH3

  • ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor.

    Mollinedo F et al (2004) Curr Med Chem 11(24) : 3163-84.
    PubMedID: 15579006
  • Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

    Powis G et al (1992) Cancer Res 52(10) : 2835-40.
    PubMedID: 1316230
  • Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition.

    Burgeiro A et al (2013) Mitochondrion 13(1) : 25-35.
    PubMedID: 23164800
  • The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.

    Na HK et al (2008) Asia Pac J Clin Nutr 17 Suppl 1 : 204-7.
    PubMedID: 18296338
Support & Resources

Reviews & Product Guides