ET-18-OCH3

(HB0278)

Product overview

  • Name
    ET-18-OCH3
  • Short description
    Selective PLC inhibitor
  • Biological description
    Selective phosphatidylinositol phospholipase (PLC) inhibitor (IC50 = 9.6 µM). Inhibits mitochondrial respiration, ERK1/2 and p38 MAPK. Also activates Fas/CD95 death receptor. Displays antitumor and apoptosis -inducing properties.
  • Biological action
    Inhibitor
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    Edelfosine; 1-octadecyl-2-O-methyl-glycero-3-phosphocholine
  • Molecular Weight
    523.7
  • Chemical structure
    ET-18-OCH3  [77286-66-9]
  • Molecular Formula
    C27H58NO6P
  • CAS Number
    77286-66-9
  • PubChem identifier
    6918215
  • SMILES
    CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC

Storing and Using Your Product

  • Solubility overview
    soluble in ethanol or DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for ET-18-OCH3

  • ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor.

    Mollinedo F et al (2004) Curr Med Chem 11(24) : 3163-84.
    PubMedID: 15579006
  • Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

    Powis G et al (1992) Cancer Res 52(10) : 2835-40.
    PubMedID: 1316230
  • Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition.

    Burgeiro A et al (2013) Mitochondrion 13(1) : 25-35.
    PubMedID: 23164800
  • The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.

    Na HK et al (2008) Asia Pac J Clin Nutr 17 Suppl 1 : 204-7.
    PubMedID: 18296338

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