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Biological Data Biological description D2 receptor antagonist which also shows some activity at D3 and D4 receptors (Ki values are 0.07, 0.16, 22.3 nM at D2 , D3 and D4 respectively). Shows antipsychotic effects. Active in vivo .
Solubility & Handling Storage instructions room temperature (desiccate)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 3-Chloro-5-ethyl-N -[[(2S )-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamid e hydrochloride
Molecular Formula C17 H25 ClN2 O3 .HCl
SMILES O=C(C2=C(OC)C(Cl)=CC(CC)=C2O)NC[C@@H]1CCCN1CC.Cl
InChiKey HFJFXXDHVWLIKX-YDALLXLXSA-N
References for Eticlopride hydrochloride References are publications that support the biological activity of the product
The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys. Claytor R et al (2006) Pharmacol Biochem Behav 83(3) : 456-64. The D3 dopamine receptor: neurobiology and potential clinical relevance. Levant B (1997) Pharmacol Rev 49(3) : 231-52. Involvement of dopamine receptors in the antipsychotic profile of (-) eticlopride. Giuliani D et al (1997) Physiol Behav 61(4) : 563-7. Morphogenic potentials of D2, D3, and D4 dopamine receptors revealed in transfected neuronal cell lines. Swarzenski BC et al (1994) Proc Natl Acad Sci U S A 91(2) : 649-53.
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