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Evans blue

(HB0280)
Data

Product overview

  • Name
    Evans blue
  • Short description
    Potent AMPA / kainate receptor antagonist. Vesicular L-glutamate uptake inhibitor.
  • Biological description
    Potent AMPA and kainate receptor antagonist (IC50 values are 150 and 220 nM for GluK2 and GluA1 respectively). Vesicular L-glutamate uptake inhibitor.. Also selective P2X-purinoceptor antagonist. Used as a dye.
  • Biological action
    Dyes & stains
  • Purity
    >95%
  • Citations

Properties

  • Chemical name
    6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4, 4'-diyl)bis(azo)bis[4-amino-5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt
  • Molecular Weight
    960.82
  • Chemical structure
    Evans blue  [314-13-6]
  • Molecular Formula
    C34H24N6Na4O14S4
  • CAS Number
    314-13-6
  • PubChem identifier
    9409
  • SMILES
    CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(C4=C(C=C3)C(=CC(=C4N)S(=O)(=O)[O-])S(=O)(=O)[O-])O)C)N=NC5=C(C6=C(C=C5)C(=CC(=C6N)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+].[Na+].[Na+]
  • InChiKey
    ATNOAWAQFYGAOY-UHFFFAOYSA-J
  • MDL number
    MFCD00004021

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Evans blue

  • Uptake of L-glutamate into synaptic vesicles: competitive inhibition by dyes with biphenyl and amino- and sulphonic acid-substituted naphthyl groups.

    Roseth S et al (1998) Biochem Pharmacol 56(9) : 1243-9.
    PubMedID: 9802337
  • P2-purinoceptor antagonists: II. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue and trypan blue.

    Wittenburg H et al (1996) Naunyn Schmiedebergs Arch Pharmacol 354(4) : 491-7.
    PubMedID: 8897453
  • Evans blue antagonizes both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates receptor desensitization.

    Price CJ et al (1996) Mol Pharmacol 50(6) : 1665-71.
    PubMedID: 8967991
  • Differential modulation of AMPA receptor mediated currents by evans blue in postnatal rat hippocampal neurones.

    Schürmann B et al (1997) Br J Pharmacol 121(2) : 237-47.
    PubMedID: 9154333
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