Product overview

Name Evans blue
Alternative names EB; T-1824
Biological description Potent AMPA and kainate receptor antagonist (IC50 values are 150 and 220 nM for GluK2 and GluA1 respectively). Vesicular L-glutamate uptake inhibitor. Also a selective P2X-purinoceptor antagonist. Commonly used as a dye.
Purity >95%
Description Potent AMPA / kainate receptor antagonist. Vesicular L-glutamate uptake inhibitor.
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Evans blue product vial image | Hello Bio

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name 6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4, 4'-diyl)bis(azo)bis[4-amino-5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt
Molecular Weight 960.82
Chemical structure Evans blue  [314-13-6] Chemical Structure
Molecular Formula C34H24N6Na4O14S4
CAS Number 314-13-6
PubChem identifier 9409
SMILES CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(C4=C(C=C3)C(=CC(=C4N)S(=O)(=O)[O-])S(=O)(=O)[O-])O)C)N=NC5=C(C6=C(C=C5)C(=CC(=C6N)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+].[Na+].[Na+]
InChiKey ATNOAWAQFYGAOY-UHFFFAOYSA-J
MDL number MFCD00004021
Appearance Blue solid

References for Evans blue

References are publications that support the biological activity of the product
  • Uptake of L-glutamate into synaptic vesicles: competitive inhibition by dyes with biphenyl and amino- and sulphonic acid-substituted naphthyl groups.

    Roseth S et al (1998) Biochem Pharmacol 56(9) : 1243-9.
  • Differential modulation of AMPA receptor mediated currents by evans blue in postnatal rat hippocampal neurones.

    Schürmann B et al (1997) Br J Pharmacol 121(2) : 237-47.
  • P2-purinoceptor antagonists: II. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue and trypan blue.

    Wittenburg H et al (1996) Naunyn Schmiedebergs Arch Pharmacol 354(4) : 491-7.
  • Evans blue antagonizes both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate receptors and modulates receptor desensitization.

    Price CJ et al (1996) Mol Pharmacol 50(6) : 1665-71.

4 Item(s)

Publications
These publications cite the use of Evans blue purchased from Hello Bio:
  • Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury

    Todd J et al (2021) J Biomed Mater Res B Appl Biomater 109(12) : 2268-2278
    PubMedID: 34117693

1 Item