Fasudil hydrochloride

(HB0283)

Product overview

  • Name
    Fasudil hydrochloride
  • Short description
    ROCK and cyclic nucleotide-dependent protein kinase inhibitor
  • Biological description
    Rho-associated kinase inhibitor (IC50 = 10.7 µM) and cyclic nucleotide-dependent protein kinase inhibitor. Inhibits NOS in microglia and pro-inflammatory factors in brain tissue. Also reduces nitric oxide, IL-1β, IL-6 and TNF. Shows antioxidant effects which can reverse hypertension and neuroprotective actions.
  • Alternative names
    HA 1077; 1-(5-Isoquinolinesulfonyl)homopiperazine, Monohydrochloride salt
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
  • Molecular Weight
    327.83
  • Chemical structure
    Fasudil hydrochloride  [105628-07-7]
  • Molecular Formula
    C14H17N3O2S.HCl
  • CAS Number
    105628-07-7
  • PubChem identifier
    163751
  • SMILES
    C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
  • InChi
    InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
  • InChiKey
    LFVPBERIVUNMGV-UHFFFAOYSA-N
  • MDL number
    MFCD00943198

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM) and in DMSO (75mM)

References for Fasudil hydrochloride

  • Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.

    Ding J et al (2010) J Neurochem 114(6) : 1619-29.
    PubMedID: 20882700
  • Fasudil reversed MCT-induced and chronic hypoxia-induced pulmonary hypertension by attenuating oxidative stress and inhibiting the expression of Trx1 and HIF-1α.

    Liu M et al (2014) Respir Physiol Neurobiol 201 : 38-46.
    PubMedID: 24973470

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