Product overview

Name Fasudil hydrochloride
Alternative names HA 1077; 1-(5-Isoquinolinesulfonyl)homopiperazine, Monohydrochloride salt
Purity >98%
Description ROCK and cyclic nucleotide-dependent protein kinase inhibitor
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Biological Data

Biological description Rho-associated kinase inhibitor (IC50 = 10.7 µM) and cyclic nucleotide-dependent protein kinase inhibitor. Inhibits NOS in microglia and pro-inflammatory factors in brain tissue. Also reduces nitric oxide, IL-1β, IL-6 and TNF. Shows antioxidant effects which can reverse hypertension and neuroprotective actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM) and in DMSO (75mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
Molecular Weight 327.83
Chemical structure Fasudil hydrochloride  [105628-07-7] Chemical Structure
Molecular Formula C14H17N3O2S.HCl
CAS Number 105628-07-7
PubChem identifier 163751
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
InChi InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
InChiKey LFVPBERIVUNMGV-UHFFFAOYSA-N
MDL number MFCD00943198

References for Fasudil hydrochloride

References are publications that support the biological activity of the product
  • Fasudil reversed MCT-induced and chronic hypoxia-induced pulmonary hypertension by attenuating oxidative stress and inhibiting the expression of Trx1 and HIF-1α.

    Liu M et al (2014) Respir Physiol Neurobiol 201 : 38-46.
  • Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice.

    Ding J et al (2010) J Neurochem 114(6) : 1619-29.

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