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Data

Product overview

  • Name
    FCCP
  • Short description
    Potent uncoupler of mitochondrial oxidative phosphorylation.
  • Biological description

    FCCP is an protonophore which is widely used to investigate the role of mitochondria in cellular function.


    FCCP is a potent uncoupler of mitochondrial oxidative phosphorylation. FCCP disrupts ATP synthesis by transporting protons across the mitochondrial inner membrane, interfering with the proton gradient.

    FCCP also induces apoptosis.


    The uncoupling agent CCCP is also available.

  • Alternative names
    Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
  • Molecular Weight
    254.17
  • Chemical structure
    FCCP [370-86-5]
  • Molecular Formula
    C10H5F3N4O
  • CAS Number
    370-86-5
  • PubChem identifier
    3330
  • SMILES
    C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F
  • Source
    Synthetic
  • InChi
    InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
  • InChiKey
    BMZRVOVNUMQTIN-UHFFFAOYSA-N
  • MDL number
    MFCD00009699
  • Appearance
    Yellow solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

References for FCCP

  • Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells.

    MS et al (2010) Arch Biochem Biophys 495(2) : 152-8
    PubMedID: 20060804
  • FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells.

    Park et al (2002) Pflugers Arch 443(3) : 344-52
    PubMedID: 11810202
  • Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.

    Brennan et al (2006) Cardiovasc Res. 72(2) : 313-21
    PubMedID: 16950237