Product overview

Name FCCP
Alternative names Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Purity >98%
Description Potent uncoupler of mitochondrial oxidative phosphorylation.
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Biological Data

Biological description

FCCP is an protonophore which is widely used to investigate the role of mitochondria in cellular function.


FCCP is a potent uncoupler of mitochondrial oxidative phosphorylation. FCCP disrupts ATP synthesis by transporting protons across the mitochondrial inner membrane, interfering with the proton gradient.

FCCP also induces apoptosis.


The uncoupling agent CCCP is also available.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Molecular Weight 254.17
Chemical structure FCCP [370-86-5] Chemical Structure
Molecular Formula C10H5F3N4O
CAS Number 370-86-5
PubChem identifier 3330
SMILES C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F
Source Synthetic
InChi InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
InChiKey BMZRVOVNUMQTIN-UHFFFAOYSA-N
MDL number MFCD00009699
Appearance Yellow solid

References for FCCP

References are publications that support the biological activity of the product
  • Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells.

    MS et al (2010) Arch Biochem Biophys 495(2) : 152-8
  • Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.

    Brennan et al (2006) Cardiovasc Res. 72(2) : 313-21
  • FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells.

    Park et al (2002) Pflugers Arch 443(3) : 344-52

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