Felodipine

(HB1222)

Product overview

  • Name
    Felodipine
  • Short description
    Selective L-type VOCC blocker
  • Biological description
    Selective L-type voltage-operated calcium channel (VOCC) blocker (pIC50 = 8.30 mM). Exhibits selectivity for L-type channels over L-, N-, P/Q-, and R-type channels. Displays vascular relaxant, vascular protective, antihypertensive and antianginal properties.
  • Biological action
    Blocker
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
  • Molecular Weight
    384.25
  • Chemical structure
    Felodipine  [72509-76-3]
  • Molecular Formula
    C18H19Cl2NO4
  • CAS Number
    72509-76-3

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Felodipine

  • Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues.

    Angus JA et al (2000) Clin Exp Pharmacol Physiol 27(12) : 1019-21.
    PubMedID: 11117223
  • Felodipine inhibits free-radical production by cytokines and glucose in human smooth muscle cells.

    Hishikawa K et al (1998) Hypertension 32(6) : 1011-5.
    PubMedID: 9856965
  • Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes.

    Furukawa T et al (1999) J Pharmacol Exp Ther 291(2) : 464-73.
    PubMedID: 10525060
  • Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists.

    Sarsero D et al (1998) Br J Pharmacol 125(1) : 109-19.
    PubMedID: 9776350

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