Fenvalerate

(HB0287)

Product overview

  • Name
    Fenvalerate
  • Short description
    Calcineurin inhibitor
  • Biological description
    Calcineurin (protein phosphatase) inhibitor. Type II pyrethroid. Prolongs sodium channel opening times and inhibits T-type Ca2+ channel currents. Impairs steroidogenesis and spermatogenesis in rodents. Shows insecticidal, anxiogenic and endocrine disrupting actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Molecular Weight
    419.9
  • Chemical structure
    Fenvalerate  [51630-58-1]
  • Molecular Formula
    C25H22ClNO3
  • CAS Number
    51630-58-1
  • PubChem identifier
    3347
  • SMILES
    CC(C)C(C1=CC=C(C=C1)Cl)C(=O)OC(C#N)C2=CC(=CC=C2)OC3=CC=CC=C3

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in ethanol (>25mg/ml) or DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Fenvalerate

  • Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.

    Enan E et al (1992) Biochem Pharmacol 43(8) : 1777-84.
    PubMedID: 1315545
  • Fenvalerate-induced Ca2+ transients via both intracellular and extracellular way in mouse GC-2spd (ts) cells.

    Wang J et al (2009) Toxicology 259(3) : 122-32.
    PubMedID: 19428952
  • Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood.

    Zhang H et al (2010) J Appl Toxicol 30(4) : 369-77.
    PubMedID: 20063364
  • Kinetic properties of single sodium channels modified by fenvalerate in mouse neuroblastoma cells.

    Holloway SF et al (1989) Pflugers Arch 414(6) : 613-21.
    PubMedID: 2554247

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