FGIN-1-27

(HB0913)

Product overview

  • Name
    FGIN-1-27
  • Short description
    Potent, selective MDR receptor agonist
  • Biological description
    Potent and selective mitochondrial diazepam binding inhibitor receptor (MDR) agonist, also known as peripheral benzodiazepine receptors. Increase Leydig cell steroid and neurosteroid production. Indirectly modulates GABAA receptors by increasing neurosteroids. Shows anti-convulsant actions. Blood-brain barrier permeable.
  • Biological action
    Agonist
  • Our products in action

Properties

  • Chemical name
    N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
  • Molecular Weight
    436.61
  • Chemical structure
    FGIN-1-27  [142720-24-9]
  • Purity
    >98%
  • Molecular Formula
    C28H37FN2O
  • CAS Number
    142720-24-9

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)

References for FGIN-1-27

  • 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).

    Romeo E et al (1992) J Pharmacol Exp Ther 262(3) : 971-8.
    PubMedID: 1326631
  • Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells.

    Chung JY et al (2013) Endocrinology 154(6) : 2156-65.
    PubMedID: 23525219
  • Development of ligands for the peripheral benzodiazepine receptor.

    James ML et al (2006) Curr Med Chem 13(17) : 1991-2001.
    PubMedID: 16842193
  • Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo.

    Korneyev A et al (1993) J Neurochem 61(4) : 1515-24.
    PubMedID: 8397297

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