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Product overview

  • Name
    FH 535
  • Short description
    Wnt/β-catenin inhibitor and PPARγ/δ antagonist.
  • Biological description
    Wnt/β-catenin inhibitor and PPARγ/δ antagonist. Reduces NO production. Shows antiproliferative and anti-cancer actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    FH 535  [108409-83-2]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (75mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for FH 535

  • A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities.

    Handeli S et al (2008) Mol Cancer Ther 7(3) : 521-9.
    PubMedID: 18347139
  • Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535.

    Gedaly R et al (2014) PLoS One 9(6) : e99272.
    PubMedID: 24940873
  • FH535 inhibits the proliferation of HepG2 cells via downregulation of the Wnt/β-catenin signaling pathway.

    Liu J et al (2014) Mol Med Rep 9(4) : 1289-92.
    PubMedID: 24482011
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