Product overview

  • Name
    FK 228
  • Short description
    Potent, selective HDAC1 / HDAC2 inhibitor
  • Biological description
    Potent and selective histone deacetylase (HDAC) inhibitor. Selective for class I HDAC1 and HDAC2 over class II HDAC4 and HDAC6 (IC50 values are 36, 47, 510 nM and 14 µM respectively). Induces human fetal hemoglobin. Shows growth inhibitory, apoptotic and anti-tumor actions.
  • Alternative names
    Romidepsin; depsipeptide
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    Cyclo[(2Z)-2-amino-2-butenoyl-L-val yl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valy l-D-cysteinyl], cyclic (3-5) disulfide
  • Molecular Weight
    540.7
  • Chemical structure
    FK 228  [128517-07-7]
  • Molecular Formula
    C24H36N4O6S2
  • CAS Number
    128517-07-7

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (10mM)

References for FK 228

  • FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

    Furumai R et al (2002) Cancer Res 62(17) : 4916-21.
    PubMedID: 12208741
  • Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo.

    Sasakawa Y et al (2002) Biochem Pharmacol 64(7) : 1079-90.
    PubMedID: 12234611
  • Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin.

    Cao H et al (2006) Am J Hematol 81(12) : 981-3.
    PubMedID: 16888791

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