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Product overview

  • Name
    FK 506
  • Short description
    Potent calcineurin phosphatase 2B inhibitor
  • Biological description
    Potent calcineurin phosphatase 2B (PP2B) inhibitor (IC50 = 2 nM). Interacts with FK-506 binding protein. Also inhibits IL-2 production by activated T-cells and reduces amount of GLUT4 on human adipocytes. Displays neuroprotective, antibiotic and immunosuppressant properties.
  • Alternative names
    Tacrolimus; Fujimycin; FK-506
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChi
  • InChiKey
  • MDL number
  • Appearance
    White to off-white

Storing and Using Your Product

  • Storage instructions
    -20 °C
  • Solubility overview
    Soluble in ethanol (100 mM) and DMSO (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for FK 506

  • Possible nitric oxide modulation in protective effect of FK-506 against 3-nitropropionic acid-induced behavioral, oxidative, neurochemical, and mitochondrial alterations in rat brain.

    Kumar P et al (2010) Drug Chem Toxicol 33(4) : 377-92.
    PubMedID: 20550427
  • The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.

    Fruman DA et al (1995) J Immunol 154(4) : 1846-51.
    PubMedID: 7530743
  • Cyclosporine A and Tacrolimus Reduce the Amount of GLUT4 at the Cell Surface in Human Adipocytes: Increased Endocytosis as a Potential Mechanism for the Diabetogenic Effects of Immunosuppressive Agents.

    Pereira MJ et al (2014) J Clin Endocrinol Metab 99(10) : E1885-94.
    PubMedID: 25004245
  • Mode of action of tacrolimus (FK506): molecular and cellular mechanisms.

    Thomson AW et al (1995) Ther Drug Monit 17(6) : 584-91.
    PubMedID: 8588225
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