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Flumazenil

(HB0915)
Data

Product overview

  • Name
    Flumazenil
  • Short description
    GABAA receptor antagonist
  • Biological description
    GABAA receptor antagonist, non-selective for α1, α2, α3 or α5 subunits. Binds at the benzodiazepine site. Used as a reversal agent for benzodiazepines. Reverses tolerance to benzodiazepines and restores the neuroprotective actions of diazepam in ischemia models.
  • Alternative names
    Ro 15-1788
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    8-Fluoro-5,6-dihydro-5-methyl-6-oxo -4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
  • Molecular Weight
    303.29
  • Chemical structure
    Flumazenil  [78755-81-4]
  • Molecular Formula
    C15H14FN3O3
  • CAS Number
    78755-81-4
  • PubChem identifier
    3373
  • SMILES
    CCOC(=O)C1=C2CN(C)C(=O)C3=CC(F)=CC=C3N2C=N1
  • InChiKey
    OFBIFZUFASYYRE-UHFFFAOYSA-N

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in DMSO (25mM, gentle warming) or ethanol (5mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Flumazenil

  • Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.

    Atack JR et al (1999) Neuropsychopharmacology 20(3) : 255-62.
    PubMedID: 10063485
  • Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.

    Iwata M et al (2012) Br J Anaesth 109(6) : 935-42.
    PubMedID: 23043146
  • Rapid and reliable sedation induced by diazepam and antagonized by flumazenil in zebra finches (Taeniopygia guttata).

    Prather JF (2012) J Avian Med Surg 26(2) : 76-84.
    PubMedID: 22872979
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