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Fluorescently labeled Muscimol TMR-X conjugate

(HB6110)
Data

Product overview

  • Name
    Fluorescently labeled Muscimol TMR-X conjugate
  • Short description
    Fluorescently labeled Muscimol
  • Biological description

    This fluorescently labelled muscimol conjugate exhibits agonist activity GABAA and GABAC receptors.


    The compound is active in vivo and shows no difference to muscimol  on long-term contextual fear. The fluorescently labeled Muscimol TMR-X conjugate can be considered to be representative for the diffusion of muscimol after dorsohippocampal administration.


    The compound can be used for visulazing the spatial gradient of reversible brain inactivations.

  • Alternative names
    Muscimol-bodipy, Muscimol-BODIPY® TMR-X conjugate (TM of Molecular Probes)
  • Biological action
    Agonist
  • Citations

Properties

  • Chemical name
    5,5-difluoro-2-(3-((6-(((3-hydroxyisoxazol-5-yl)methyl)amino)-6-oxohexyl)amino)-3-oxopropyl)-7-(4-methoxyphenyl)-1,3-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
  • Molecular Weight
    607.46
  • Molecular Formula
    C31H36BF2N5O5
  • Excitation
    544
  • Emission
    570

Storing and Using Your Product

  • Storage instructions
    Store at -20°C (desiccate, protect from light)
  • Solubility overview
    Soluble in DMSO and in MeOH
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Fluorescently labeled Muscimol TMR-X conjugate

  • GABA(A) receptor activation in the CA1 area of the dorsal hippocampus impairs consolidation of conditioned contextual fear in C57BL/6J mice.

    Misane et al (2013) Behav Brain Res. 238 : 160-9
    PubMedID: 23098796
  • Imaging the spread of reversible brain inactivations using fluorescent muscimol.

    Allen (2008) J Neurosci Methods 171(1) : 30-8
    PubMedID: 18377997
  • Activation of membrane receptors by a neurotransmitter conjugate designed for surface attachment.

    Vu et al (2005) Biomaterials 26(14) : 1895-903
    PubMedID: 15576163
Our products in action
The following papers have cited the use of Fluorescently labeled Muscimol TMR-X conjugate (HB6110) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Silent learning

    Rossato et al (2018) Current Biology 28 : 1-8
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