Fluoxetine hydrochloride

(HB1600)

Product overview

  • Name
    Fluoxetine hydrochloride
  • Short description
    Selective 5-HT uptake inhibitor
  • Biological description
    Potent, selective 5-HT reuptake inhibitor (Ki = 2 nM at rSERT). Also acts at other receptors and channels. Shows ~150-900 fold selectivity over 5-HT1a,-2A, muscarinic, α1, α2-adrenoceptors and H1 receptors. Shows antidepressant effects. Active in vivo.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
  • Molecular Weight
    345.78
  • Chemical structure
    Fluoxetine hydrochloride  [56296-78-7]
  • Molecular Formula
    C17H18F3NO.HCl
  • CAS Number
    56296-78-7
  • PubChem identifier
    62857
  • SMILES
    CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl
  • InChi
    InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
  • InChiKey
    GIYXAJPCNFJEHY-UHFFFAOYSA-N
  • MDL number
    MFCD00214288

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (10mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Fluoxetine hydrochloride

  • Fluoxetine, a selective inhibitor of serotonin uptake.

    Fuller RW et al (1991) Med Res Rev 11(1) : 17-34.
    PubMedID: 1994152
  • Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors.

    Wong DT et al (1990) Acta Pharm Nord 2(3) : 171-80.
    PubMedID: 2200429
  • Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.

    Benfield P et al (1986) Drugs 32(6) : 481-508.
    PubMedID: 2878798

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