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Fluticasone propionate


Product overview

  • Name
    Fluticasone propionate
  • Short description
    Selective glucocorticoid receptor agonist
  • Biological description
    Selective glucocorticoid receptor agonist (Kd = 0.5 nM). Reduces expression of mast cells, suppresses mast cell degranulation, enhances eosinophil apoptosis and inhibits T cell proliferation. Potentiates Kv1 channel current (EC50 = 37 nM). Shows anti-inflammatory and anti-allergy actions.
  • Biological action
  • Citations


  • Chemical name
    (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
  • Molecular Weight
  • Chemical structure
    Fluticasone propionate  [80474-14-2]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Fluticasone propionate

  • The anti-inflammatory profile of fluticasone propionate.

    Johnson M (1995) Allergy 50(23 Suppl) : 11-4.
    PubMedID: 7604948
  • Basic research on virus-induced asthma exacerbation: inhibition of inflammatory chemokine expression by fluticasone propionate.

    Matsukura S et al (2013) Int Arch Allergy Immunol 161 Suppl 2 : 84-92.
    PubMedID: 23711858
  • Potentiation of the Kv1 family K(+) channel by cortisone analogues.

    Pan Y et al (2012) ACS Chem Biol 7(10) : 1641-6.
    PubMedID: 22803826
  • Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone.

    Zhang X et al (2000) Eur J Pharmacol 406(3) : 325-32.
    PubMedID: 11040338
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