Fostriecin sodium salt

(HB0293)

Product overview

  • Name
    Fostriecin sodium salt
  • Short description
    Potent protein phosphatase inhibitor
  • Biological description
    Potent protein phosphatase inhibitor. Inhibits PP4, PP2A, PP5C and PP1 (IC50 values are 3, 3.2 nM, 60 and 131 µM). Shows antibiotic and antitumor actions
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z ,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt
  • Molecular Weight
    452.37
  • Chemical structure
    Fostriecin sodium salt  [87860-39-7]
  • Molecular Formula
    C19H26O9PNa
  • CAS Number
    87860-39-7
  • PubChem identifier
    73324802
  • SMILES
    CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]
  • InChi
    InChI=1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1
  • InChiKey
    XBUIKNRVGYFSHL-UHFFFAOYSA-M
  • MDL number
    MFCD09971059

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (100mM)

References for Fostriecin sodium salt

  • Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.

    Walsh AH et al (1997) FEBS Lett 416(3) : 230-4.
    PubMedID: 9373158
  • Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.

    Hastie CJ et al (1998) FEBS Lett 431(3) : 357-61.
    PubMedID: 9714542
  • Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death.

    Theobald B et al (2013) Mol Cancer Res 11(8) : 845-55.
    PubMedID: 23671329

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