Product overview

Name Fostriecin sodium salt
Purity >98%
Description Potent protein phosphatase inhibitor
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Biological Data

Biological description Potent protein phosphatase inhibitor. Inhibits PP4, PP2A, PP5C and PP1 (IC50 values are 3, 3.2 nM, 60 and 131 µM). Shows antibiotic and antitumor actions

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z ,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt
Molecular Weight 452.37
Chemical structure Fostriecin sodium salt  [87860-39-7] Chemical Structure
Molecular Formula C19H26O9PNa
CAS Number 87860-39-7
PubChem identifier 73324802
SMILES CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]
InChi InChI=1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1
InChiKey XBUIKNRVGYFSHL-UHFFFAOYSA-M
MDL number MFCD09971059

References for Fostriecin sodium salt

References are publications that support the biological activity of the product
  • Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death.

    Theobald B et al (2013) Mol Cancer Res 11(8) : 845-55.
  • Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.

    Hastie CJ et al (1998) FEBS Lett 431(3) : 357-61.
  • Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.

    Walsh AH et al (1997) FEBS Lett 416(3) : 230-4.

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