The store will not work correctly in the case when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Biological Data Biological description Antibiotic. Inhibits protein synthesis to show cytotoxic activity.
Widely used in cell culture as a selection antibiotic for the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3' or APH II.
Also shows antiviral activity and induces apoptosis.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name O-2-Amino-2,7-dideoxy-D-glycero-α-D-glucoheptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-D-streptamine sulfate
Chemical structure
Molecular Formula C20 H40 N4 O10 .2H2 SO4
PubChem identifier 16218858
SMILES CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
InChi InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
InChiKey UHEPSJJJMTWUCP-DHDYTCSHSA-N
References for G418 disulfate salt References are publications that support the biological activity of the product
A novel kanamycin/G418 resistance marker for direct selection of transformants in Escherichia coli and different yeast species. Agaphonov et al (2010) Yeast 27(4) : 189-95 The effects of G418 on the growth and metabolism of recombinant mammalian cell lines. Yallop and Svendsen (2001) Cytotechnology 35(2) : 101-14 Use of plasmid-mediated resistance to the antibiotic G418 for the rapid screening of a yeast mutant library. Chenevert et al (1984) J Exp Pathol 1(4) : 307-13
Publications
These publications cite the use of G418 disulfate salt purchased from Hello Bio:
Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms Bibic L et al (2019) J Nat Prod 82(9) : 2559-2567
Antibiotic. Widely used in cell culture. Protein synthesis inhibitor.
![G418 disulfate salt [108321-42-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3906_3.png "G418 disulfate salt [108321-42-2]")
Understanding purity and quality - a guide for life scientists
