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G418 disulfate salt

(HB3906)
Data

Product overview

  • Name
    G418 disulfate salt
  • Short description
    Antibiotic. Widely used in cell culture. Protein synthesis inhibitor.
  • Biological description

    Antibiotic. Inhibits protein synthesis to show cytotoxic activity.

    Widely used in cell culture for the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3' or APH II.

    Also shows antiviral activity and induces apoptosis.

  • Biological action
    Antibiotic
  • Applications
    Cell Culture, Plant Culture, Selection Agent
  • Citations

Properties

  • Chemical name
    O-2-Amino-2,7-dideoxy-D-glycero-α-D-glucoheptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-D-streptamine sulfate
  • Molecular Weight
    692.71
  • Chemical structure
    G418 disulfate salt [108321-42-2]
  • Molecular Formula
    C20H40N4O10.2H2SO4
  • CAS Number
    108321-42-2
  • PubChem identifier
    16218858
  • SMILES
    CC([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@H]3[C@H]([C@@H]([C@](CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
  • InChi
    InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
  • InChiKey
    UHEPSJJJMTWUCP-DHDYTCSHSA-N
  • MDL number
    MFCD00058314
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4 °C
  • Solubility overview
    Soluble in water (100 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for G418 disulfate salt

  • The effects of G418 on the growth and metabolism of recombinant mammalian cell lines.

    Yallop and Svendsen (2001) Cytotechnology 35(2) : 101-14
    PubMedID: 19003287
  • A novel kanamycin/G418 resistance marker for direct selection of transformants in Escherichia coli and different yeast species.

    Agaphonov et al (2010) Yeast 27(4) : 189-95
    PubMedID: 20014045
  • Use of plasmid-mediated resistance to the antibiotic G418 for the rapid screening of a yeast mutant library.

    Chenevert et al (1984) J Exp Pathol 1(4) : 307-13
    PubMedID: 6400641
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