GABA

(HB0882)

Product overview

  • Name
    GABA
  • Short description
    Endogenous inhibitory neurotransmitter
  • Biological description

    Main endogenous inhibitory neurotransmitter. Activates ionotropic GABAA and GABAA-ρ receptors and metabotropic GABAB receptors. Also induces α-cell-mediated β-like endocrine cell neogenesis in vivo.

  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    4-Aminobutyric acid
  • Molecular Weight
    103.12
  • Chemical structure
    GABA  [56-12-2]
  • Molecular Formula
    C4H9NO2
  • CAS Number
    56-12-2
  • PubChem identifier
    119
  • SMILES
    C(CC(=O)O)CN
  • InChi
    InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
  • InChiKey
    BTCSSZJGUNDROE-UHFFFAOYSA-N
  • MDL number
    MFCD00008226

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for GABA

  • GABAc receptors: relatively simple transmitter -gated ion channels?

    Johnston GA (1996) Trends Pharmacol Sci 17(9) : 319-23.
    PubMedID: 8885697
  • GABA and GABA receptors in the central nervous system and other organs.

    Watanabe M et al (2002) Int Rev Cytol 213 : 1-47.
    PubMedID: 11837891
  • GABA: a dominant neurotransmitter in the hypothalamus.

    Decavel C et al (1990) J Comp Neurol 302(4) : 1019-37.
    PubMedID: 2081813
  • Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy.

    Leke R et al (2011) J Neurochem 117(5) : 824-32.
    PubMedID: 21395584
  • Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.

    Ben-Othman et al (2017) Cell. 168(1-2): : 73-85
    PubMedID: 27916274