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Data

Product overview

  • Name
    Gabapentin
  • Short description
    Glutamate release inhibitor / VSCC modulator
  • Biological description
    K+-evoked glutamate release inhibitor. Thought to interact with the voltage-sensitive Ca2+ channel (VSCC), binding at the α2δ subunit. Inhibits K+-induced cytosolic Ca2+ increase (IC50 = 14 µM). Increases the expression of Il-10 and decreases pro-inflammatory cytokines to show actions against neuropathic pain. Also shows anticonvulsant, analgesic and anti-epileptic actions.

    Please note that this product is only for sale in the US and Canada

  • Alternative names
    GBP | Neurontin
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    1-(Aminomethyl)cyclohexaneacetic acid
  • Molecular Weight
    171.24
  • Chemical structure
    Gabapentin  [60142-96-3]
  • Molecular Formula
    C9H17NO2
  • CAS Number
    60142-96-3
  • PubChem identifier
    3446
  • SMILES
    C1CCC(CC1)(CC(=O)O)CN
  • InChi
    InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
  • InChiKey
    UGJMXCAKCUNAIE-UHFFFAOYSA-N
  • MDL number
    MFCD00865286
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    Soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. Please note that this product is only for sale in the US and Canada.

References for Gabapentin

  • Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain.

    Lee BS et al (2013) J Korean Med Sci 28(2) : 308-14.
    PubMedID: 23399960
  • Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ α2δ-1 subunit.

    Quintero JE et al (2011) J Pharmacol Exp Ther 338(1) : 240-5.
    PubMedID: 21464332
  • Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices.

    Fink K et al (2000) Br J Pharmacol 130(4) : 900-6.
    PubMedID: 10864898
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