Gabapentin

(HB0857)

Product overview

  • Name
    Gabapentin
  • Short description
    Glutamate release inhibitor / VSCC modulator
  • Biological description
    K+-evoked glutamate release inhibitor. Thought to interact with the voltage-sensitive Ca2+ channel (VSCC), binding at the α2δ subunit. Inhibits K+-induced cytosolic Ca2+ increase (IC50 = 14 µM). Increases the expression of Il-10 and decreases pro-inflammatory cytokines to show actions against neuropathic pain. Also shows anticonvulsant, analgesic and anti-epileptic actions.
  • Alternative names
    GBP | Neurontin
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    1-(Aminomethyl)cyclohexaneacetic acid
  • Molecular Weight
    171.24
  • Chemical structure
    Gabapentin  [60142-96-3]
  • Molecular Formula
    C9H17NO2
  • CAS Number
    60142-96-3

Storing and Using Your Product

  • Storage instructions
    +4°C (desiccate)
  • Solubility overview
    soluble in water (100mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Gabapentin

  • Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain.

    Lee BS et al (2013) J Korean Med Sci 28(2) : 308-14.
    PubMedID: 23399960
  • Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ α2δ-1 subunit.

    Quintero JE et al (2011) J Pharmacol Exp Ther 338(1) : 240-5.
    PubMedID: 21464332
  • Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices.

    Fink K et al (2000) Br J Pharmacol 130(4) : 900-6.
    PubMedID: 10864898

Reviews & Product Guides