Ganaxolone
(HB0938)
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Professor Graham Collingridge
Code: HB0901
Pack: 10mg,50mg,10mM (add 1ml water)
Code: HB0895
Pack: 25mg,50mg,125mg
Code: HB0506
Pack: 1g,5x1g
Ganaxolone
(HB0938)- Data
- Support & Resources
Product overview
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Name
Ganaxolone
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Short description
Potent GABAA receptor positive allosteric modulator
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Biological description
Potent GABAA receptor positive allosteric modulator (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Neuroactive steroid; enhances [3H]flunitrazepam binding (EC50 = 125 nM). Decreases ethanol consumption in addiction models and shows actions against Multiple Sclerosis. Shows sedative, anxiolytic and anticonvulsant effects. Blood-brain barrier permeable.
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Biological action
PAM
- Citations
Properties
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Chemical name
(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
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Molecular Weight
332.53
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Chemical structure
![Ganaxolone [38398-32-2]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "Ganaxolone [38398-32-2]")
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Molecular Formula
C22H36O2
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CAS Number
38398-32-2
![Ganaxolone [38398-32-2]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb0938.png "Ganaxolone [38398-32-2]")
Storing and Using Your Product
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Storage instructions
+4°C
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Solubility overview
soluble in DMSO (100mM) or ethanol (100mM)
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Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Ganaxolone
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Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.
Carter RB et al (1997) J Pharmacol Exp Ther 280(3) : 1284-95.PubMedID: 9067315 -
Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
Ramaker MJ et al (2012) Neuropharmacology 63(4) : 555-64.PubMedID: 22613838 -
GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.
Paul AM et al (2014) Neuroscience 273 : 24-38.PubMedID: 24814730
Reviews & Product Guides
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