Ganaxolone
(HB0938)
Quick stock solutions with mM EasyPacks!
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Code: HB0901
Pack: 10mg,50mg,10mM (add 1ml water)
Code: HB0895
Pack: 25mg,50mg,125mg
Code: HB0506
Pack: 1g,5x1g
Ganaxolone
(HB0938)- Data
- Support & Resources
Product overview
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NameGanaxolone
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Short descriptionPotent GABAA receptor positive allosteric modulator
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Biological descriptionPotent GABAA receptor positive allosteric modulator (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Neuroactive steroid; enhances [3H]flunitrazepam binding (EC50 = 125 nM). Decreases ethanol consumption in addiction models and shows actions against Multiple Sclerosis. Shows sedative, anxiolytic and anticonvulsant effects. Blood-brain barrier permeable.
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Biological actionPAM
- Citations
Properties
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Chemical name(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
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Molecular Weight332.53
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Chemical structure
![Ganaxolone [38398-32-2]](data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs= "Ganaxolone [38398-32-2]")
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Molecular FormulaC22H36O2
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CAS Number38398-32-2
![Ganaxolone [38398-32-2]](https://www.hellobio.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/h/b/hb0938.png "Ganaxolone [38398-32-2]")
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in DMSO (100mM) or ethanol (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Ganaxolone
Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.
Carter RB et al (1997) J Pharmacol Exp Ther 280(3) : 1284-95.PubMedID: 9067315Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
Ramaker MJ et al (2012) Neuropharmacology 63(4) : 555-64.PubMedID: 22613838GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.
Paul AM et al (2014) Neuroscience 273 : 24-38.PubMedID: 24814730
Reviews & Product Guides
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