Pack	Price	Qty
50mg	$407

Ganaxolone

(HB0938)

Product overview

Name
Ganaxolone
Short description
Potent GABA_A receptor positive allosteric modulator
Biological description
Potent GABA_A receptor positive allosteric modulator (EC₅₀ values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Neuroactive steroid; enhances [3H]flunitrazepam binding (EC₅₀ = 125 nM). Decreases ethanol consumption in addiction models and shows actions against Multiple Sclerosis. Shows sedative, anxiolytic and anticonvulsant effects. Blood-brain barrier permeable.
Biological action
PAM
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Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.
Carter RB et al (1997) J Pharmacol Exp Ther 280(3) : 1284-95.
PubMedID: 9067315
Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
Ramaker MJ et al (2012) Neuropharmacology 63(4) : 555-64.
PubMedID: 22613838
GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.
Paul AM et al (2014) Neuroscience 273 : 24-38.
PubMedID: 24814730