Pack	Price	Qty
50mg	$407

Ganaxolone

(HB0938)

Product overview

Name
Ganaxolone
Short description
Potent GABA_A receptor positive allosteric modulator
Biological description
Potent GABA_A receptor positive allosteric modulator (EC₅₀ values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Neuroactive steroid; enhances [3H]flunitrazepam binding (EC₅₀ = 125 nM). Decreases ethanol consumption in addiction models and shows actions against Multiple Sclerosis. Shows sedative, anxiolytic and anticonvulsant effects. Blood-brain barrier permeable.
Biological action
PAM
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Storage instructions
+4°C
Solubility overview
soluble in DMSO (100mM) or ethanol (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.
Carter RB et al (1997) J Pharmacol Exp Ther 280(3) : 1284-95.
PubMedID: 9067315
Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.
Ramaker MJ et al (2012) Neuropharmacology 63(4) : 555-64.
PubMedID: 22613838
GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.
Paul AM et al (2014) Neuroscience 273 : 24-38.
PubMedID: 24814730