Ganaxolone

(HB0938)

Product overview

  • Name
    Ganaxolone
  • Short description
    Potent GABAA receptor positive allosteric modulator
  • Biological description
    Potent GABAA receptor positive allosteric modulator (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Neuroactive steroid; enhances [3H]flunitrazepam binding (EC50 = 125 nM). Decreases ethanol consumption in addiction models and shows actions against Multiple Sclerosis. Shows sedative, anxiolytic and anticonvulsant effects. Blood-brain barrier permeable.
  • Biological action
    PAM
  • Citations

Properties

  • Chemical name
    (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
  • Molecular Weight
    332.53
  • Chemical structure
    Ganaxolone  [38398-32-2]
  • Molecular Formula
    C22H36O2
  • CAS Number
    38398-32-2

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ganaxolone

  • Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

    Carter RB et al (1997) J Pharmacol Exp Ther 280(3) : 1284-95.
    PubMedID: 9067315
  • Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration.

    Ramaker MJ et al (2012) Neuropharmacology 63(4) : 555-64.
    PubMedID: 22613838
  • GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.

    Paul AM et al (2014) Neuroscience 273 : 24-38.
    PubMedID: 24814730

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