Ganglioside GD1a disodium salt

(HB0296)

Product overview

  • Name
    Ganglioside GD1a disodium salt
  • Short description
    Endogenous ganglioside
  • Biological description
    Endogenous ganglioside. Suppresses murine FBJ osteosarcoma cells from metastasizing and suppresses hepatocyte growth factor (HGF) expression. Activates ERK 1 / 2 MAP kinases and EGFR; regulates stem cell differentiation into osteoblasts. Acts as a coreceptor for Toll-like receptor 2 (TLR2).
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    Disialoganglioside GD1a.2Na
  • Molecular Weight
    1882.04
  • Molecular Formula
    C84H146N4O39.2Na
  • CAS Number
    12707-58-3
  • PubChem identifier
    44145122
  • SMILES
    CCCCCCCCCCCCCCCCCC(=O)N[C@@H](COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)OC5(CC([C@H](C(O5)[C@H]([C@H](CO)O)O)NC(=O)C)O)C(=O)[O-])O)O)NC(=O)C)OC6(CC([C@H](C(O6)[C@H]([C@H](CO)O)O)NC(=O)C)O)C(=O)[O-])O)O)O)[C@@H](/C=C/CCCCCCCCCCCCCCC)O.[Na+].[Na+]

Storing and Using Your Product

  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ganglioside GD1a disodium salt

  • Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells.

    Zhang L et al (2011) Biochim Biophys Acta 1810(8) : 759-68.
    PubMedID: 21554929
  • Inhibition of ganglioside GD1a synthesis suppresses the differentiation of human mesenchymal stem cells into osteoblasts.

    Yang HJ et al (2011) Dev Growth Differ 53(3) : 323-32.
    PubMedID: 21492147
  • Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin.

    Liang S et al (2007) J Biol Chem 282(10) : 7532-42.
    PubMedID: 17227759

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