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Data

Product overview

  • Name
    GANT 58
  • Short description
    GLI1 antagonist. Hedgehog signaling inhibitor.
  • Biological description
    GLI1 antagonist. Hedgehog (Hh) signaling inhibitor (IC50 = 5 μM for inhibition of Hh signaling downstream of Smo and Sufu at the level of Gli). Induces apoptosis.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    2,3,4,5-Tetra(4-pyridyl)thiophene
  • Molecular Weight
    392.48
  • Chemical structure
    GANT 58 |  [64048-12-0]
  • Molecular Formula
    C24H16N4S
  • CAS Number
    64048-12-0

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (25mM) or ethanol (25mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for GANT 58

  • Small-molecule modulators of the Sonic Hedgehog signaling pathway.

    Stanton and Peng (2010) Mol Biosyst 6(1) : 44-54
    PubMedID: 20024066
  • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.

    Lauth et al (2007) Proc Natl Acad Sci U S A 104(20) : 8455-60
    PubMedID: 17494766
  • Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells.

    Hou et al (50-9) Biochimie 2014 : 101
    PubMedID: 24394624
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