Product overview

Name GANT61
Purity >98%
Description GLI antagonist. Also Hedgehog (Hh) signaling inhibitor.
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Biological Data

Biological description Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Additionally inhibits hedgehog (Hh) signaling pathway, downstream of SMO and SUFU. Displays antiproliferative, antitumor and apoptosis inducing activity. Also inhibits pluripotency maintaining factors c-Myc, Nanog, Oct4, Sox-2 in pancreatic cancer stem cells.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >98%
Chemical name 2,2'-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine
Molecular Weight 429.6
Chemical structure GANT61 | NSC 136476  [500579-04-4] Chemical Structure
Molecular Formula C27H35N5
CAS Number 500579-04-4
PubChem identifier 421610
SMILES CN(C1=CC=CC=C1CN2CCCN(CC4=C(N(C)C)C=CC=C4)C2C3=CC=NC=C3)C
InChiKey KVQOGDQTWWCZFX-UHFFFAOYSA-N
Appearance White to off-white solid