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GBR 12909 dihydrochloride

(HB1812)
Data

Product overview

  • Name
    GBR 12909 dihydrochloride
  • Short description
    Potent, competitive dopamine uptake inhibitor
  • Biological description
    Potent, competitive dopamine uptake inhibitor (Ki = 1 nM). Also a potent Kv11.1, and Na+ and Ca+ channel blocker (IC50 values are 0.8, 320 and 830 nM at hKv11.1, hICa,L and hNav1.5 respectively and σ receptor blocker). Shows variety of biological actions. Active in vivo.
  • Alternative names
    Vanoxerine
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
  • Molecular Weight
    523.49
  • Chemical structure
    GBR 12909 dihydrochloride  [67469-78-7]
  • Molecular Formula
    C28H32F2N2O.2HCl
  • CAS Number
    67469-78-7
  • PubChem identifier
    104920
  • SMILES
    C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
  • InChi
    InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
  • InChiKey
    MIBSKSYCRFWIRU-UHFFFAOYSA-N
  • MDL number
    MFCD00055193

Storing and Using Your Product

  • Storage instructions
    Room temperature (desiccate)
  • Solubility overview
    Soluble in water (25 mM, gentle warming) and in DMSO (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for GBR 12909 dihydrochloride

  • The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action.

    Andersen PH (1989) Eur J Pharmacol 166(3) : 493-504.
    PubMedID: 2530094
  • Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery.

    Espaã±a RA et al (2008) Neuroscience 155(1) : 250-7.
    PubMedID: 18597947
  • Vanoxerine: cellular mechanism of a new antiarrhythmic.

    Lacerda AE et al (2010) J Cardiovasc Electrophysiol 21(3) : 301-10.
    PubMedID: 19817928
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