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Genistein

(HB2775)
Data

Product overview

  • Name
    Genistein
  • Short description
    Protein tyrosine kinase inhibitor and PPARγ agonist. Phytoestrogen.
  • Biological description
    Phytoestrogen. Protein tyrosine inhibitor and PPARγ and PPARα agonist (Ki values = 5.7 nM at PPARγ). Also binds estrogen receptors to exert weak estrogenic activity. Shows variety of biological actions.
  • Biological action
    Agonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    5,7-Dihydroxy-3-(4-hydroxyphenyl)-4 H-1-benzopyran-4-one
  • Molecular Weight
    270.24
  • Chemical structure
    Genistein
  • Molecular Formula
    C15H10O5
  • CAS Number
    446-72-0

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Genistein

  • Genistein, a specific inhibitor of tyrosine-specific protein kinases.

    Akiyama T et al (1987) J Biol Chem 262(12) : 5592-5.
    PubMedID: 3106339
  • Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.

    Wang L et al (2014) Biochem Pharmacol 92(1) : 73-89.
    PubMedID: 25083916
  • Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer.

    Nakamura H et al (2011) PLoS One 6(5) : e20034.
    PubMedID: 21603581
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